Prostate MRI protocol (mpMRI)
Multiparametric imaging where precision decides a PI-RADS score. You are detecting and staging cancer across three parameters: high-resolution T2 for anatomy, high-b DWI for cellularity and dynamic contrast for kinetics. The planning is unforgiving.
By the ScanFlo Editorial Team · Updated
In this section · Protocols
When this study is used
- Suspected prostate cancer (raised PSA, abnormal DRE): detection and PI-RADS scoring.
- Local staging of known cancer.
- Active-surveillance follow-up.
Patient & coil positioning
- Head-first supine, straight and centred; arms crossed on the chest to keep them out of the pelvic FOV.
- Comfortably full bladder pushes bowel away from the prostate and reduces motion; an anti-peristalsis agent (glucagon/Buscopan) is often given to still the bowel.
- Body array coil centred at the pubic symphysis; strap the pelvis and thighs.
Localizer
Three-plane localizer. Sagittal from the bladder dome through the perineum; axial showing both femoral heads and the sacrum.
Sequence planning
For each sequence below you get the reference line the slice group follows, how much it covers, and why the sequence is in the protocol at all. Plan against the localizer, not by eye.
High-res axial-oblique T2
Axial obliquePlanning: Strictly perpendicular to the rectal wall at the prostate, usually a ~15° anterior tilt from true axial. Seminal vesicles to the apex.
Why: Zonal anatomy, capsular integrity and extracapsular extension. This is the backbone of staging.
High-b-value DWI (b≈1500) + ADC
Axial obliquePlanning: Match the T2 plane; reduced-FOV (ZOOMit) technique cuts distortion from rectal gas.
Why: Cellularity: malignant lesions restrict (bright DWI, dark ADC). PI-RADS leans heavily on DWI.
Dynamic contrast (DCE) T1 fat-sat
AxialPlanning: Repeated over the gland after injection for wash-in/wash-out kinetics.
Why: Detects and characterises lesions, especially in the transition zone.
T2 sagittal + coronal-oblique
Sagittal / coronal obliquePlanning: Coronal parallel to the prostatic urethra; sagittal along the midline.
Why: Seminal-vesicle and apical assessment; neurovascular-bundle involvement.
Representative parameters
Treat these as ranges. Field strength, coil and vendor all move the numbers. What must not move is understanding why each sits where it does.
| Sequence | Matrix / FOV | Notes |
|---|---|---|
| Axial-oblique T2 | 320–384 / 16–20 cm | Perpendicular to rectal wall |
| DWI (b≈1500) | reduced FOV | ADC map essential; b=50/800/1500 |
| DCE T1 FS | temporal ~10 s | Wash-in/wash-out kinetics |
| T2 sag / cor-oblique | 320 / 16–20 cm | Staging planes |
Artifacts & how to fix them
| Artifact | Typical cause | Mitigation |
|---|---|---|
| Bowel motion | Peristalsis despite glucagon | Anterior sat bands; single-shot T2; reduced-FOV DWI |
| DWI distortion | Rectal gas, susceptibility | Reduced-FOV (ZOOMit); micro-enema; higher NEX |
| Hip-implant blooming | Metal prosthesis | High bandwidth; TSE over GRE; MARS if available |
| Motion from bladder filling | Over-full bladder | Comfortably full bladder, not over-full |
What am I looking at?
You are not reporting the study, but recognising pathology helps you keep it in the field of view and know when to add a sequence or contrast. How the common findings read on the console:
| Finding | Sequence to check | How it reads |
|---|---|---|
| Peripheral-zone cancer (T2) | Axial-oblique T2 | Dark, ill-defined focus with spiculated margins in the bright PZ |
| Cancer (diffusion) | High-b DWI + ADC | Bright on high-b DWI, correspondingly dark on ADC |
| Extracapsular extension | T2 sag/cor-oblique | Tumour breaching the capsule or seminal-vesicle involvement |
Review checklist
- T2 planned strictly perpendicular to the rectal wall.
- DWI acquired at high b-value with a clean ADC map.
- Whole gland covered including apex and seminal vesicles.
- DCE timed for wash-in/wash-out kinetics.
Mistakes that cost repeats
- A true-axial (non-oblique) T2 misjudging capsular extension.
- DWI so distorted by rectal gas that there is no usable ADC.
- Over-full bladder driving motion rather than reducing it.
- Omitting the ADC map that PI-RADS depends on.
Common questions
- Why plan prostate T2 perpendicular to the rectal wall?
- That angulation (roughly a 15° tilt from true axial) gives the truest view of the peripheral zone, capsule and neurovascular bundles, which is what determines whether cancer has extended beyond the gland.
- Why is high-b-value DWI central to prostate MRI?
- Cancer packs cells densely and restricts water diffusion. High-b DWI makes that restriction conspicuous: bright on DWI and dark on the ADC map. PI-RADS scoring in the peripheral zone is driven primarily by the DWI/ADC finding.
- Why give an anti-peristalsis agent and manage the bladder?
- Bowel peristalsis is a major source of pelvic motion; glucagon or Buscopan quiets it. A comfortably full bladder pushes bowel away from the prostate and improves image quality. An over-full bladder, though, causes its own motion.
Try it in ScanFlo: Plan a T2 stack perpendicular to the rectal wall, then a true-axial one, and compare how the capsule and peripheral zone look. The perpendicular plane is what lets you judge extracapsular extension, and that is the difference between staging correctly and under-staging. See ScanFlo MRI →